Thomas D. Brown, PhD

Richard and Janice Johnston Professor of Orthopaedic Biomechanics
Director, Orthopaedic Biomechanics Laboratory

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Education

• 1965–1967 Metallurgy and Materials Science, Case Institute of Technology, Cleveland, OH
• 1972 B.S. Mechanical Engineering, (Honors) University of Maryland, College Park, MD
• 1973 M.S. Mechanical Engineering-Bioengineering, Carnegie-Mellon University, Pittsburgh, PA
• 1976 Ph.D. Mechanical Engineering-Bioengineering, Carnegie-Mellon University, Pittsburgh, PA

Professional and Academic Positions

• 1976–1981 Research Assistant Professor of Orthopaedics, University of Pittsburgh, Pittsburgh, PA
• 1976–1981 Research Assistant Professor of Civil Engineering, University of Pittsburgh, Pittsburgh, PA
• 1981–1983 Research Associate Professor of Orthopaedics, University of Pittsburgh, Pittsburgh, PA
• 981–1983 Research Associate Professor of Civil Engineering, University of Pittsburgh, Pittsburgh, PA
• 1981–1983 Lecturer of Engineering in Medicine, Biomedical Engineering Program Carnegie-Mellon University, Pittsburgh, PA
• 1983–1987 Associate Professor of Orthopaedic Surgery, College of Medicine, University of Iowa, Iowa City, IA (Primary Appointment)
• 1983–1987 Associate Professor of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA (Secondary Appointment)
• 1983–1998 Co-Director, Biomechanics Laboratory, Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA
• 1998–Present Director, Biomechanics Laboratory, Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA
• 1987–Present Professor of Orthopaedic Surgery, College of Medicine, University of Iowa, Iowa City, IA (Primary Appointment)
• 1987–Present Professor of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, IA (Secondary Appointment)
• 1997–2000 Richard C. Johnston Professor of Orthopaedic Biomechanics, University of Iowa, Iowa City, IA
• 2000–Present Richard and Janice Johnston Chair of Orthopaedic Biomechanics, University of Iowa, Iowa City, IA

Honors and Awards

• 1967 General Motors Scholar
• 1972 Elected to Tau Beta Pi and Pi Tau Sigma Engineering Honorary Societies
• 1972 American Society for Testing and Materials Research Prize in Mechanical Metallurgy
• 1976 National Institutes of Health Training Grant Recipient
• 1977 Doctoral Thesis Nominated for Lorenz Straub National Hydraulics Award
• 1978 Elected to Sigma Xi Honorary Society
• 1984 Giovani Borelli Award, American Society of Biomechanics
• 1986 Kappa Delta Award, American Academy of Orthopaedic Surgeons
• 1993 Frank Stinchfield Award, The Hip Society
• 1993 President, American Society of Biomechanics
• 1994 Fellow, American Institute for Medical and Biological Engineering
• 1994 Clinical Biomechanics Award, American Society of Biomechanics
• 1996 Frank Stinchfield Award, The Hip Society
• 1997 William H. Harris Award, Orthopaedic Research Society
• 1997 Frank Stinchfield Award, The Hip Society
• 1997 J. Albert Key Award, Mid-America Orthopaedic Association
• 1998 Clinical Biomechanics Award, American Society of Biomechanics
• 1999 Journal of Biomechanics Award, American Society of Biomechanics
• 2001 Göran Selvik Award, European Orthopaedic Research Society
• 2001 Microstrain Award, American Society of Biomechanics
• 2001 Mark Coventry Award, The Knee Society
• 2001 Clinical Biomechanics Award, American Society of Biomechanics
• 2001 President, Orthopaedic Research Society
• 2002 Clinical Biomechanics Award, American Society of Biomechanics
• 2003 Orthopaedic Research and Education Foundation Clinical Research Award, American Academy of Orthopaedic Surgeons
• 2009 Nicolas Andry Award, Association of Bone and Joint Surgeons

Recent Publications and Reviews

• Kang L, Galvin AL, Brown TD, Jin Z, Fisher J. Quantification of the effect of crossshear on the wear of conventional and highly cross-linked UHMWPE. J. Biomech. 2008;41(2):340–346. PMC2239346.
• Lundberg HJ, Liu SS, Callaghan JJ, Pedersen DR, O’Rourke MR, Goetz DD, Vittetoe D, Clohisy JC, Brown TD. Association of 3rd body embedment with rim damage in retrieved acetabular liners. Clin. Orthop. Rel. Res. 2007 Dec;465:133–139.
• McKinley TO, Rudert MJ, Tochigi Y, Brown TD. Instability-associated changes in contact stress and contact stress rates in human cadaveric ankles. J. Bone Joint Surg. Am. 2008;90(2):375–383. PMC2587164.
• Goetz JE, Derrick TR, Pedersen DR, Robinson DA, Conzemius MG, Baer TE, Brown TD. Hip joint contact force in the emu (Dromaius novaehollandiae) during normal level walking. J. Biomech. 2008;41(4):770–778. PMC2291359.
• Thomas TP, Anderson DD, Marsh JL, Brown TD. A method for the estimation of normative bone surface area to aid in objective CT-based fracture severity assessment. Iowa Orthop. J. 2008;28:9–13. PMC2603343.
• Li W, Anderson DD, Goldsworthy J, Marsh JL, Brown TD. Patient-specific finite element analysis of chronic contact stress exposure after intra-articular fracture of the tibial plafond. J. Orthop. Res. 2008;26(8):1039–1045. PMC2562934.
• Anderson DD, Mosqueda TV, Thomas TP, Hermanson EL, Brown TD, Marsh JL. Quantifying tibial plafond fracture severity: Absorbed energy and fragment displacement agree with clinical rank ordering. J. Orthop. Res. 2008;26(8):1046–1052. PMC2562904.
• Heiner AD, Lundberg HJ, Baer TE, Pedersen DR, Callaghan JJ, Brown TD. Effects of episodic subluxation events on third body ingress and embedment in the THA bearing surface. J. Biomech. 2008;41(10):2090–2096. PMC2572990.
• Heiner AD, Callaghan JJ, Brown TD. Stability differentials for proximal versus distal fusion of THA femoral impaction grafts. J. Arthroplasty. 2008;23(6):921–926. PMC2604125.
• Glennon LP, Baer TE, Martin JA, Lack WD, Brown TD. Sliding directiondependence of polyethylene wear for metal counterface traverse of severe scratches. J. Biomech. Eng. 2008 Oct;130(5): 051006. PMC2593892.
• Goetz JE, Pedersen DR, Robinson DA, Conzemius MG, Baer TE, Brown TD. The apparent critical isotherm for cryoinsult-induced osteonecrotic lesions in emu femoral heads. J. Biomech. 2008;41(10):2197–2205. PMC2612542.
• Brown TD, Bartel DL. What design factors influence wear behavior at the bearing surfaces in total joint replacements? Journal of the American Academy of Orthopaedic Surgeons (JAAOS). 2008;16:S101–S106.
• Paul MC, Glennon LP, Baer TE, Brown TD. Field variable associations with scratch orientation-dependence of UHMWPE wear: A finite element analysis. J. Biomech. Eng. 2008 Dec;130(6):061019. PMC2593842.
• Tochigi Y, Rudert MJ, McKinley TO, Pedersen DR, Brown TD. Correlation of dynamic cartilage contact stress aberrations with severity of instability in ankle incongruity. J. Orthop. Res. 2008;26(9):1186–1193. PMC Journal – In Process.
• McKinley TO, Tochigi Y, Rudert MJ, Brown TD. The effect of incongruity and instability on contact stress directional gradients in human cadaveric ankles. Osteoarthritis Cartilage. 2008 Nov;16(11):1363–1369. PMC2592197.
• Kang L, Galvin AL, Brown, TD, Jin Z, Fisher J. Wear simulation of UHMWPE hip implants by incorporating the effects of cross-shear and contact pressure. Proc. Inst. Mech. Eng. [H]. 2008;222:1049–1064.
• Brown TD, Callaghan JJ. Impingement in total hip replacement: Mechanisms and consequences. Curr. Orthop. 2008;22(6): 376–391. PMC2652485.
• Moussavi-Harami SF, Pedersen DR, Martin JA, Hillis SL, Brown TD. Automated objective scoring of histologically apparent cartilage degeneration using a custom image analysis program. J. Orthop. Res. 2009;27(4):522–528. PMC Journal – In Process.
• Segal NA, Anderson DD, Iyer KS, Baker J, Torner JC, Lynch JA, Felson DT, Lewis CE, Brown TD. Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort J. Orthop. Res. 2009;27:1562– 1568.
• Brown TD, Lundberg HJ, Pedersen DR, Callaghan JJ. 2009 Nicolas Andry Award: Clinical biomechanics of third body acceleration of total hip wear. Clin. Orthop. Relat. Res. 2009;467(7):1885–1897. PMC2690766.
• Altenburg AJ, Callaghan JJ, Yehyawi TM, Pedersen DR, Liu SS, Leinen JA, Dahl KA, Goetz DD, Brown TD, Johnston RC. The effect of cable debris on acetabular construction durability in cemented total hip arthroplasty at 19 to 20 year follow-up. J. Bone Joint Surg. Am. 2009 Jul;91(7):1664–70. PMC2702252.
• Hartmann JM, Rudert MJ, Pedersen DR, Baer TE, Goreham-Voss CM, Brown TD. Compliance-dependent load allocation between sensing versus non-sensing portions of a sheet-array contact stress sensor. Iowa Orthop. J. 2009;29:43–47. PMC2723691.
• Troy KL, Brown TD, Conzemius MG. Contact stress distributions on the femoral head of the emu (Dromaius novaehollandiae). J. Biomech. 2009;42(15):2495–2500. PMC2783888.
• Thomas TP, Van Hofwegen CJ, Anderson DD, Brown TD, Marsh JL. Utility of double-contrast multi-detector CT scans to assess cartilage thickness after tibial plafond fracture. Orthop. Res. Reviews. 2009;1; 23–29. PMC2903754.
• Kunze NM, Goetz JE, Thedens DR, Baer TE, Lawler EA, Brown TD. Individual flexor tendon identification within the carpal tunnel: A semi-automated analysis method for serial cross-section MR images. Orthop. Res. Reviews. 2009;1:31–42. NIHMS190467.
• Anderson DD, Iyer K, Segal NA, Lynch JA, Brown TD. Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure. J. Appl. Biomech. 2010;2:215–223.
• Anderson DD, Tochigi Y, Rudert MJ, Vaseenon T, Brown TD, Amendola A. Effect of implantation accuracy on ankle contact mechanics with a metallic focal resurfacing implant. J. Bone Joint Surg. [Am] 2010;92:1490–1500.
• Goreham-Voss CM, Hyde PJ, Hall RM, Fisher J, Brown TD. Cross-shear implementation in sliding-distance-coupled finite element analysis of wear in metalon-polyethylene total joint arthroplasty: Intervertebral total disc replacement as an illustrative application. J. Biomech. 2010;43(9):1674–1681.
• Kang L, Baer TE, Rudert MJ, Pedersen DR, Brown TD. Traveling-load calibration of grid-array transient contact stress sensors. J. Biomech. 2010 May 25. [Epub ahead of print]
• Marsh JL, McKinley TO, Dirschl DR, Pick AG, Haft G, Anderson DD, Brown TD. The sequential recovery of health status after tibial plafond fracture. J. Orthop. Trauma. (In press)
• Goetz JE, Thedens DR, Kunze NM, Lawler EA, Brown TD. Day-to-day variability of median nerve location within the carpal tunnel. Clin. Biomech. 2010;25:660–665. NIHMS211236.
• Rumery MP, Pedersen DR, Mendoza SA, Siepe C, Mayer HM, Brown TD. A posebased image analysis technique for measuring in vivo wear of total disc replacements. Comput. Methods Biomech. Biomed. Engin. Manuscript ID: GCMB- 2007-0059. (Accepted pending minor revision)
• Thomas TP, Anderson DD, Mosqueda TV, Van Hofwegen CJ, Hillis SL, Marsh JL, Brown TD. Objective CT-based metrics of articular fracture severity to assess risk for post-traumatic osteoarthritis. J. Orthop. Trauma. 2009. (Accepted)
• Thomas TP, Anderson DD, Willis AR, Lui P, Frank MC, Marsh JL, Brown TD. A computational/experimental platform for investigating three-dimensional puzzle solving of comminuted articular fractures. Comput. Methods Biomech. Biomed. Engin. 2010 (Accepted).
• Masrouha KZ, Anderson DD, Thomas TP, Kuhl LL, Brown TD, Marsh JL. Acute articular fracture severity and chronic cartilage stress challenge as quantitative risk factors for post-traumatic osteoarthritis: Illustrative cases. Iowa Orthop. J. 2010;30:47–54.
• Anderson DD, Van Hofwegen CJ, Marsh JL, Brown TD. Is elevated contact stress predictive of post-traumatic osteoarthritis for imprecisely reduced tibial plafond fractures? J. Orthop. Res. (Accepted). NIHMS217763.
• Goreham-Voss CM, Vicars R, Hall RM, Brown TD. Preferential superior surface motion in wear simulations of the Charité total disc replacement. Eur. Spine J.(Accepted)